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Query: YTHDC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
YTHDC2 0 -0.535 0.600 -0.450 -0.093 0.335 -0.408 0.096

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
YTHDC2 Phosphorylation S1202 0.292 _KSS(ph)ADTEFSDECTTAER_
YTHDC2 Phosphorylation S1090 0.029 0.054 _VDGIPNDSS(ph)DSEMEDK_
YTHDC2 Phosphorylation S1092 0.243 0.044 _VDGIPNDSSDS(ph)EMEDK_
YTHDC2 Ubiquitylation K647 -0.039 _ILFDDK(gl)R_
YTHDC2 Phosphorylation S1277 -1.483 -0.763 _GS(ph)KSPSPRPNM(ox)PVR_
YTHDC2 Phosphorylation S1223 -1.388 -0.856 _VLM(ox)KSPS(ph)PALHPPQK_
YTHDC2 Phosphorylation S1279 -1.244 -0.940 _GSKS(ph)PSPRPNMPVR_
YTHDC2 Phosphorylation S1221 -1.516 -1.234 _VLM(ox)KS(ph)PSPALHPPQK_
YTHDC2 Ubiquitylation K1426 -0.961 _LPLGEK(gl)NTTD_

Background Information for YTHDC2:


Pubmed-YTHDC2 »
Uniprot-YTHDC2 »
Biogrid-YTHDC2 »
ProteomicsDB-YTHDC2 »

Tumorportal-YTHDC2 »
COSMIC-YTHDC2 »
GenomeRNAi-YTHDC2 »
Genecards-YTHDC2


Protein-protein Interactions for YTHDC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLTSCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF323 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF324B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF512 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF550 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in YTHDC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members YTH_domain IPR007275 0.08
Category members DUF1605 IPR011709 0.02
Category members R3H_ss-bd IPR001374 0
Category members Ankyrin_rpt IPR002110 0
Category members Helicase-assoc_dom IPR007502 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring YTHDC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring YTHDC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79


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