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Query: VARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VARS 0 1.321 -0.490 0.240 0.482 0.547 -0.320 -0.520 -0.170

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VARS Ubiquitylation K433 0.248 0.470 _K(gl)LGSSLDWDR_
VARS Ubiquitylation K645 -0.066 _AVLVALK(gl)ER_
VARS Ubiquitylation K432 -0.399 _IYHQLK(gl)K_
VARS Ubiquitylation K246 0.455 _EKLEK(gl)FQQK_
VARS Ubiquitylation K952 0.592 _HFCNK(gl)LWNATK_

Background Information for VARS:


Pubmed-VARS »
Uniprot-VARS »
Biogrid-VARS »
ProteomicsDB-VARS »

Tumorportal-VARS »
COSMIC-VARS »
GenomeRNAi-VARS »
Genecards-VARS


Protein-protein Interactions for VARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait ABTB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CORO1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOSL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Glutathione-S-Trfase_C-like IPR010987 0.23
Category members Val/Leu/Ile-tRNA-synth_edit IPR009008 0.08
Category members V/L/I-tRNA-synth_anticodon-bd IPR013155 0.08
Category members tRNA-bd_arm IPR010978 0.08
Category members aa-tRNA-synth_Ia IPR002300 0
Category members Valyl-tRNA_ligase IPR002303 0
Category members Glutathione_S-Trfase_N IPR004045 0
Category members GST_C IPR004046 0
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0


Protein complexes (CORUM database) featuring VARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006414 translational elongation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0002161 aminoacyl-tRNA editing activity Database 0.23
Category members Pathway Pathway_47 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0 0.09
Category members GO Category GO:0004832 valine-tRNA ligase activity Database 0
Category members GO Category GO:0006438 valyl-tRNA aminoacylation Database 0


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