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Query: SRP72

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRP72 1 6.055 -0.720 1.160 -0.154 -0.285 0.465 0.085

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRP72 Ubiquitylation K383 0.772 1.160 _LTMAQLK(gl)ISQGNISK_
SRP72 Phosphorylation S620 0.892 _TVS(ph)SPPTSPR_
SRP72 Ubiquitylation K391 0.804 0.532 _ISQGNISK(gl)ACLILR_
SRP72 Phosphorylation S621 1.276 -0.247 _TVSS(ph)PPTSPR_
SRP72 Phosphorylation S625 -1.396 _TVSS(ph)PPTS(ph)PRPGSAATVSASTSNIIPPR_
SRP72 Phosphorylation T618 1.927 -1.548 _T(ph)VSSPPT(ph)SPRPGSAATVSASTSNIIPPR_

Background Information for SRP72:


Pubmed-SRP72 »
Uniprot-SRP72 »
Biogrid-SRP72 »
ProteomicsDB-SRP72 »

Tumorportal-SRP72 »
COSMIC-SRP72 »
GenomeRNAi-SRP72 »
Genecards-SRP72


Protein-protein Interactions for SRP72
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait IBTK Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF19 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP68 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRP72
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93


Protein complexes (CORUM database) featuring SRP72
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SRP72
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0048500 signal recognition particle Database 0.62
Category members GO Category GO:0005786 signal recognition particle, endoplasmic reticulum targeting Database 0.46
Category members GO Category GO:0008312 7S RNA binding Database 0.31
Category members GO Category GO:0005047 signal recognition particle binding Database 0


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