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Query: SRP68

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRP68 0 0.936 -0.060 -0.090 -0.839 0.550 -0.102 0.189 0.244

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRP68 Ubiquitylation K142 0.584 _AWSYAMQLK(gl)QEANTEPR_
SRP68 Ubiquitylation K288 -0.158 _AK(gl)QAATMSEVEWR_
SRP68 Ubiquitylation K416 0.310 -0.458 _ALLQQQPEDDSK(gl)R_
SRP68 Ubiquitylation K400 -0.957 _NENMAK(gl)GLQR_
SRP68 Ubiquitylation K360 0.258 -1.000 _EELKPDQK(gl)QR_

Background Information for SRP68:


Pubmed-SRP68 »
Uniprot-SRP68 »
Biogrid-SRP68 »
ProteomicsDB-SRP68 »

Tumorportal-SRP68 »
COSMIC-SRP68 »
GenomeRNAi-SRP68 »
Genecards-SRP68


Protein-protein Interactions for SRP68
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FBXO21 Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait AXDND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPB41L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIMAP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MKI67IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP68 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRP68
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SRP68
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SRP68
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005840 ribosome Database 12.2
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0005786 signal recognition particle, endoplasmic reticulum targeting Database 0.46
Category members GO Category GO:0008312 7S RNA binding Database 0.31
Category members GO Category GO:0030942 endoplasmic reticulum signal peptide binding Database 0.08
Category members GO Category GO:0005047 signal recognition particle binding Database 0


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