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Query: SRP54

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRP54 0 3.747 -0.230 1.030 0.312 0.726 0.409

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRP54 Ubiquitylation K457 0.551 0.586 _NVSQSQMAK(gl)LNQQMAK_
SRP54 Ubiquitylation K442 0.374 _GLFK(gl)GGDMSK_
SRP54 Ubiquitylation K448 0.684 0.065 _GGDMSK(gl)NVSQSQMAK_
SRP54 Ubiquitylation K464 0.437 0.019 _LNQQMAK(gl)MMDPR_
SRP54 Ubiquitylation K398 -1.121 _VFSK(gl)QPGR_
SRP54 Ubiquitylation K323 0.436 _LK(gl)HGQFTLR_

Background Information for SRP54:


Pubmed-SRP54 »
Uniprot-SRP54 »
Biogrid-SRP54 »
ProteomicsDB-SRP54 »

Tumorportal-SRP54 »
COSMIC-SRP54 »
GenomeRNAi-SRP54 »
Genecards-SRP54


Protein-protein Interactions for SRP54
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CXorf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIMAP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP68 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRP54
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members MobB-typ_P-loop IPR029007 0.21
Category members CobW/HypB/UreG_dom IPR003495 0.04
Category members Signal_recog_particl_SRP54_hlx IPR013822 0
Category members SRP54_GTPase_dom IPR000897 0
Category members CobQ/CobB/MinD/ParA_Nub-bd_dom IPR002586 0


Protein complexes (CORUM database) featuring SRP54
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SRP54
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0045047 protein targeting to ER Database 0.62
Category members GO Category GO:0048500 signal recognition particle Database 0.62
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0005786 signal recognition particle, endoplasmic reticulum targeting Database 0.46
Category members GO Category GO:0008312 7S RNA binding Database 0.31
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0030942 endoplasmic reticulum signal peptide binding Database 0.08
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0


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