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Query: SPTLC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPTLC1 0 0.201 0.110 -0.670
SPTLC1 0 0.201 0.110 -0.670 -0.731 -0.718

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPTLC1 Ubiquitylation K197 0.964 _AACFAIQK(gl)GLQASR_
SPTLC1 Ubiquitylation K127 0.685 0.734 _AAALASLKK(gl)_
SPTLC1 Ubiquitylation K207 0.061 _SDIK(gl)LFK_

Background Information for SPTLC1:


Pubmed-SPTLC1 »
Uniprot-SPTLC1 »
Biogrid-SPTLC1 »
ProteomicsDB-SPTLC1 »

Tumorportal-SPTLC1 »
COSMIC-SPTLC1 »
GenomeRNAi-SPTLC1 »
Genecards-SPTLC1


Protein-protein Interactions for SPTLC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP7A Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait JAK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5B Cat. description Hein, Mann, Cell 2015
Category members IP bait SPTLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TCEAL4 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZW10 Cat. description Hein, Mann, Cell 2015


Protein Domains in SPTLC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Aminotransferase_I/II IPR004839 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring SPTLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2863 Serine-palmitoyltransferase (SPT) complex Database 0


Categories featuring SPTLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0009058 biosynthetic process Database 0.11
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_127 KEGG_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_128 REACTOME_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_498 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 0 0
Category members Disease phenotype Hereditary_sensory_and_autonomic_neuropathy_type_1 Hereditary sensory and autonomic neuropathy type 1 Database 0
Category members GO Category GO:0004758 serine C-palmitoyltransferase activity Database 0
Category members GO Category GO:0006665 sphingolipid metabolic process Database 0
Category members GO Category GO:0006686 sphingomyelin biosynthetic process Database 0
Category members GO Category GO:0017059 serine C-palmitoyltransferase complex Database 0
Category members GO Category GO:0030148 sphingolipid biosynthetic process Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0046511 sphinganine biosynthetic process Database 0
Category members GO Category GO:0046512 sphingosine biosynthetic process Database 0
Category members GO Category GO:0046513 ceramide biosynthetic process Database 0


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