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Query: SPRY4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPRY4 0 -1.898 -0.020 -0.290

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPRY4 Phosphorylation S125 -1.153 _LLDHMAPPPVADQAS(ph)PR_
SPRY4 Ubiquitylation K291 -0.745 _AASGDAK(gl)TSRPDKPF_

Background Information for SPRY4:


Pubmed-SPRY4 »
Uniprot-SPRY4 »
Biogrid-SPRY4 »
ProteomicsDB-SPRY4 »

Tumorportal-SPRY4 »
COSMIC-SPRY4 »
GenomeRNAi-SPRY4 »
Genecards-SPRY4


Protein-protein Interactions for SPRY4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ORMDL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPRY4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPRY4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Sprouty IPR007875 0.1


Protein complexes (CORUM database) featuring SPRY4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPRY4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_1071 BIOCARTA_SPRY_PATHWAY 0 0
Category members Disease phenotype Kallmann_Syndrome Kallmann Syndrome Database 0
Category members Disease phenotype Normosmic_congenital_hypogonadotropic_hypogonadism Normosmic congenital hypogonadotropic hypogonadism Database 0
Category members Disease phenotype Testicular_non_seminomatous_germ_cell_tumor Testicular non seminomatous germ cell tumor Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0


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