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Query: SPOP

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPOP 0 1.091 -0.190 -0.380

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPOP Ubiquitylation K110 0.132 0.107 _FSILNAK(gl)GEETK_
SPOP Ubiquitylation K64 0.984 _SSTFSSGANDK(gl)LK_
SPOP Ubiquitylation K66 0.984 _SSTFSSGANDK(gl)LK_

Background Information for SPOP:


Pubmed-SPOP »
Uniprot-SPOP »
Biogrid-SPOP »
ProteomicsDB-SPOP »

Tumorportal-SPOP »
COSMIC-SPOP »
GenomeRNAi-SPOP »
Genecards-SPOP


Protein-protein Interactions for SPOP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARIH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MSRB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYD88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFWD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RTN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOST Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPOP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BTB/POZ-like IPR000210 0.43
Category members BTB/POZ_fold IPR011333 0.36
Category members BTB_POZ IPR013069 0.32
Category members MATH IPR002083 0
Category members TRAF-like IPR008974 0


Protein complexes (CORUM database) featuring SPOP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1225 Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) Database 0.08
Category members Corum 1243 Ubiquitin E3 ligase (SPOP, DAXX, CUL3) Database 0.04
Category members Corum 1224 Ubiquitin E3 ligase (BMI1, SPOP, CUL3) Database 0


Categories featuring SPOP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031463 Cul3-RING ubiquitin ligase complex Database 0


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