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Query: SMEK1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMEK1 0 1.451 -0.540 0.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMEK1 Phosphorylation S741 0.510 0.584 _TNLSGRQS(ph)PSFK_
SMEK1 Phosphorylation S737 0.361 0.325 _TNLS(ph)GRQSPSFK_
SMEK1 Ubiquitylation K242 -0.318 -0.055 _EFLTK(gl)TAK_
SMEK1 Phosphorylation S117 -0.494 -0.249 _DPSVDITQDLVDES(ph)EEERFDDMSSPGLELPSCELSR_
SMEK1 Phosphorylation S774 -1.933 _TNLTSQSSTTNLPGSPGSPGS(ph)PGSPGSPGSVPK_
SMEK1 Phosphorylation S777 -2.347 -2.140 _TNLTSQSSTTNLPGSPGSPGSPGS(ph)PGSPGSVPK_
SMEK1 Phosphorylation S780 -2.228 _TNLTSQSSTTNLPGSPGSPGSPGSPGS(ph)PGSVPK_

Background Information for SMEK1:


Pubmed-SMEK1 »
Uniprot-SMEK1 »
Biogrid-SMEK1 »
ProteomicsDB-SMEK1 »

Tumorportal-SMEK1 »
COSMIC-SMEK1 »
GenomeRNAi-SMEK1 »
Genecards-SMEK1


Protein-protein Interactions for SMEK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADCYAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALKBH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC120 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRAMP1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MARCKSL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMPCB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP4R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHPN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMEK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members WH1/EVH1 IPR000697 0


Protein complexes (CORUM database) featuring SMEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SMEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0030289 protein phosphatase 4 complex Database 0
Category members GO Category GO:0045722 positive regulation of gluconeogenesis Database 0


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