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Query: SAMHD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SAMHD1 0 0.816 -1.310 1.710 -1.149

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SAMHD1 Ubiquitylation K304 0.096 _SFLYEIVSNK(gl)R_
SAMHD1 Phosphorylation T592 -0.300 -0.277 _NFTKPQDGDVIAPLIT(ph)PQKK_
SAMHD1 Ubiquitylation K446 0.736 -0.441 _EILK(gl)QIEYR_
SAMHD1 Phosphorylation S33 -1.505 -0.926 _TPSNTPSAEADWS(ph)PGLELHPDYK_
SAMHD1 Ubiquitylation K469 -1.478 _YVGETQPTGQIKIK(gl)_
SAMHD1 Ubiquitylation K11 -1.378 _ADSEQPSK(gl)RPR_
SAMHD1 Ubiquitylation K66 -0.849 _GGFEEPVLLK(gl)NIR_
SAMHD1 Ubiquitylation K98 -0.338 _K(gl)KLLSYIQR_
SAMHD1 Ubiquitylation K99 -0.519 _K(gl)LLSYIQR_
SAMHD1 Ubiquitylation K405 -0.247 _ADDYIEITGAGGK(gl)K_
SAMHD1 Ubiquitylation K406 -0.323 _ADDYIEITGAGGKK(gl)_
SAMHD1 Ubiquitylation K486 -0.956 _EVASAKPK(gl)VLLDVK_
SAMHD1 Ubiquitylation K560 -0.560 _K(gl)SLYAAR_

Background Information for SAMHD1:


Pubmed-SAMHD1 »
Uniprot-SAMHD1 »
Biogrid-SAMHD1 »
ProteomicsDB-SAMHD1 »

Tumorportal-SAMHD1 »
COSMIC-SAMHD1 »
GenomeRNAi-SAMHD1 »
Genecards-SAMHD1


Protein-protein Interactions for SAMHD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NAA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMHD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SAMHD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HD/PDEase_dom IPR003607 0.07
Category members SAM IPR001660 0
Category members HD_domain IPR006674 0
Category members SAM_2 IPR011510 0
Category members SAM/pointed IPR013761 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring SAMHD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SAMHD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Disease phenotype Aicardi-Goutieres_Syndrome Aicardi-Goutieres Syndrome Database 0.05
Category members GO Category GO:0008081 phosphoric diester hydrolase activity Database 0
Category members GO Category GO:0045088 regulation of innate immune response Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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