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Query: SAE1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SAE1 2 5.088 0.560 0.110 -0.654 0.035 -0.589

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SAE1 Phosphorylation S185 1.902 2.028 _VS(ph)QGVEDGPDTK_
SAE1 Ubiquitylation K32 0.407 1.132 _LWGLEAQK(gl)R_
SAE1 Ubiquitylation K141 -0.025 0.314 _DVIVK(gl)VDQICHK_
SAE1 Ubiquitylation K148 1.235 0.292 _VDQICHK(gl)NSIK_
SAE1 Ubiquitylation K228 -0.252 _EALEVDWSSEK(gl)AK_
SAE1 Ubiquitylation K230 -0.370 -0.252 _EALEVDWSSEKAK(gl)_
SAE1 Ubiquitylation K209 -0.409 _AKLDSSETTMVKK(gl)_
SAE1 Ubiquitylation K195 -0.432 -0.461 _VSQGVEDGPDTK(gl)R_
SAE1 Ubiquitylation K198 0.543 _AK(gl)LDSSETTMVK_
SAE1 Ubiquitylation K208 -0.219 _AKLDSSETTMVK(gl)K_
SAE1 Ubiquitylation K210 0.220 _K(gl)VVFCPVK_

Background Information for SAE1:


Pubmed-SAE1 »
Uniprot-SAE1 »
Biogrid-SAE1 »
ProteomicsDB-SAE1 »

Tumorportal-SAE1 »
COSMIC-SAE1 »
GenomeRNAi-SAE1 »
Genecards-SAE1


Protein-protein Interactions for SAE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SAE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SUMO3 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait UBA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2I Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SAE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBQ/SUMO-activ_enz_E1-like IPR000011 0.29
Category members ThiF_NAD_FAD-bd IPR000594 0.19
Category members Molybdenum_cofac_synth_MoeB IPR009036 0.19


Protein complexes (CORUM database) featuring SAE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5755 SUMO1-SUA1-UBA2 complex Database 0.49
Category members Corum 5756 SUA1-UBA2 complex Database 0.2


Categories featuring SAE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0043008 ATP-dependent protein binding Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0008641 small protein activating enzyme activity Database 0.26
Category members GO Category GO:0019948 SUMO activating enzyme activity Database 0.2
Category members GO Category GO:0008047 enzyme activator activity Database 0.15
Category members GO Category GO:0004839 ubiquitin activating enzyme activity Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0016874 ligase activity Database 0


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