bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SACS

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SACS 1 5.121 -0.630 0.790 0.535 0.833 -0.083

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SACS Phosphorylation S1779 2.723 _IADLQS(ph)PLFR_
SACS Phosphorylation S4264 0.321 -0.680 _DSAPSTPTS(ph)PTEFLTPGLR_
SACS Phosphorylation S2345 -1.535 _PFS(ph)FILVENAYVDSEK_
SACS Phosphorylation T4263 0.323 _DSAPSTPT(ph)SPTEFLTPGLR_

Background Information for SACS:


Pubmed-SACS »
Uniprot-SACS »
Biogrid-SACS »
ProteomicsDB-SACS »

Tumorportal-SACS »
COSMIC-SACS »
GenomeRNAi-SACS »
Genecards-SACS


Protein-protein Interactions for SACS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NAA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM29 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENPP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MOCS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SACS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ubiquitin-like IPR000626 1.61
Category members HATPase_C IPR003594 1.07
Category members DnaJ_domain IPR001623 0.3


Protein complexes (CORUM database) featuring SACS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SACS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0070628 proteasome binding Database 0.46
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0030544 Hsp70 protein binding Database 0.1
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0070852 cell body fiber Database 0


.

© Copyright Svejstrup Laboratory 2015