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Query: RPL10

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RPL10 2 5.993 -0.990 1.530 0.489 0.084 -0.434
RPL10 2 5.993 -0.990 1.530 0.406 -0.427 -0.126 0.294
RPL10 2 5.993 -0.230 0.580 0.489 0.084 -0.434
RPL10 2 5.993 -0.230 0.580 0.406 -0.427 -0.126 0.294

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RPL10 Ubiquitylation K78 0.405 1.729 _YMVK(gl)SCGK_
RPL10 Ubiquitylation K82 1.587 1.639 _SCGK(gl)DGFHIR_
RPL10 Ubiquitylation K188 0.560 1.631 _FNADEFEDMVAEK(gl)R_
RPL10 Ubiquitylation K74 0.300 1.501 _ICANK(gl)YMVK_
RPL10 Ubiquitylation K30 0.779 1.467 _GVPDAK(gl)IR_
RPL10 Ubiquitylation K208 -0.366 1.356 _GPLDK(gl)WR_
RPL10 Ubiquitylation K101 0.264 1.342 _INK(gl)MLSCAGADR_
RPL10 Ubiquitylation K121 -0.165 0.888 _GAFGK(gl)PQGTVAR_

Background Information for RPL10:


Pubmed-RPL10 »
Uniprot-RPL10 »
Biogrid-RPL10 »
ProteomicsDB-RPL10 »

Tumorportal-RPL10 »
COSMIC-RPL10 »
GenomeRNAi-RPL10 »
Genecards-RPL10


Protein-protein Interactions for RPL10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4S1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf9;SUCO Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP120 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNTROB Cat. description Hein, Mann, Cell 2015
Category members IP bait CTDSPL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ECT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA50 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NES Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PHAX Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMO Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait WAPAL Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait AAMP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RPL10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ribosomal_L10e IPR001197 0.28
Category members Ribosomal_L10e/L16 IPR016180 0.06


Protein complexes (CORUM database) featuring RPL10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 306 Ribosome, cytoplasmic Database INF
Category members Corum 308 60S ribosomal subunit, cytoplasmic Database INF


Categories featuring RPL10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_369 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 0 INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members Pathway Pathway_768 REACTOME_PEPTIDE_CHAIN_ELONGATION 0 INF
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_772 KEGG_RIBOSOME 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003735 structural constituent of ribosome Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0006414 translational elongation Database INF
Category members GO Category GO:0006415 translational termination Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0019083 viral transcription Database INF
Category members GO Category GO:0022625 cytosolic large ribosomal subunit Database INF
Category members GO Category GO:0005840 ribosome Database 12.2
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0005622 intracellular Database 0.32


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