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Query: PLRG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PLRG1 1 4.252 -0.840 1.890 -0.256 0.296 0.721 -0.880 -0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PLRG1 Ubiquitylation K363 1.698 0.906 _LWDLVAGK(gl)TR_
PLRG1 Ubiquitylation K372 1.592 -0.745 _VTLTNHK(gl)K_
PLRG1 Ubiquitylation K373 1.592 -0.745 _VTLTNHK(gl)K_
PLRG1 Ubiquitylation K135 -0.015 _MPSESAAQSLAVALPLQTK(gl)ADANR_

Background Information for PLRG1:


Pubmed-PLRG1 »
Uniprot-PLRG1 »
Biogrid-PLRG1 »
ProteomicsDB-PLRG1 »

Tumorportal-PLRG1 »
COSMIC-PLRG1 »
GenomeRNAi-PLRG1 »
Genecards-PLRG1


Protein-protein Interactions for PLRG1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BACH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC12 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRNKL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNW1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLRG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPIE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PLRG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring PLRG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 1182 CDC5L core complex Database 0.08


Categories featuring PLRG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0


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