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Query: PHF6

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PHF6 0 2.402 1.190 -1.240
PHF6 0 2.402 1.190 -1.240 -0.231 1.024 0.574 0.337 0.324

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PHF6 Phosphorylation S155 -0.390 -0.194 _KTAHNSEAADLEESFNEHELEPS(ph)SPK_
PHF6 Phosphorylation S156 -0.359 -0.212 _TAHNSEAADLEESFNEHELEPSS(ph)PK_
PHF6 Phosphorylation S155 -0.420 -0.306 _TAHNSEADLEESFNEHELEPSS(ph)PK_
PHF6 Phosphorylation S146 -0.529 -0.395 _KTAHNSEAADLEES(ph)FNEHELEPSSPK_
PHF6 Phosphorylation S183 0.345 -0.410 _STS(ph)SHGTDEMESSSYR_
PHF6 Ubiquitylation K170 0.223 _K(gl)TNFKGLSEDTR_
PHF6 Ubiquitylation K174 0.223 _K(gl)TNFKGLSEDTR_

Background Information for PHF6:


Pubmed-PHF6 »
Uniprot-PHF6 »
Biogrid-PHF6 »
ProteomicsDB-PHF6 »

Tumorportal-PHF6 »
COSMIC-PHF6 »
GenomeRNAi-PHF6 »
Genecards-PHF6


Protein-protein Interactions for PHF6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EDEM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015


Protein Domains in PHF6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15


Protein complexes (CORUM database) featuring PHF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PHF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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