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Query: PGRMC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PGRMC1 0 1.348 -0.030 0.740 -0.063 -0.102 -0.106 0.220 -0.024

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PGRMC1 Phosphorylation S154 0.383 _EALKDEYDDLSDLTAAQQETLS(ph)DWESQFTFK_
PGRMC1 Ubiquitylation K102 0.115 0.152 _VFDVTK(gl)GR_
PGRMC1 Phosphorylation Y180 -0.062 _LLKEGEEPTVY(ph)SDEEEPKDESAR_
PGRMC1 Phosphorylation S181 -0.030 -0.212 _EGEEPTVYS(ph)DEEEPKDESAR_
PGRMC1 Phosphorylation T178 -0.196 -0.388 _EGEEPT(ph)VYSDEEEPKDESAR_
PGRMC1 Ubiquitylation K105 -1.237 -1.007 _K(gl)FYGPEGPYGVFAGR_
PGRMC1 Phosphorylation S57 -1.069 -1.271 _GDQPAASGDS(ph)DDDEPPPLPR_
PGRMC1 Phosphorylation S54 -0.398 -1.547 _GDQPAAS(ph)GDSDDDEPPPLPR_
PGRMC1 Ubiquitylation K96 -0.670 _ILMAINGK(gl)VFDVTK_
PGRMC1 Ubiquitylation K172 -1.786 _LLK(gl)EGEEPTVYSDEEEPKDESAR_

Background Information for PGRMC1:


Pubmed-PGRMC1 »
Uniprot-PGRMC1 »
Biogrid-PGRMC1 »
ProteomicsDB-PGRMC1 »

Tumorportal-PGRMC1 »
COSMIC-PGRMC1 »
GenomeRNAi-PGRMC1 »
Genecards-PGRMC1


Protein-protein Interactions for PGRMC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait B3GNT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FECH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PGRMC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyt_B5-like_heme/steroid-bd IPR001199 1.28


Protein complexes (CORUM database) featuring PGRMC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1990 PGRMC1-SCAP complex Database 0


Categories featuring PGRMC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0005496 steroid binding Database 0


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