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Query: PFKFB3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFKFB3 0 0.903 1.130 -0.750 -0.354 0.299

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFKFB3 Phosphorylation T477 0.387 0.207 _RNSVT(ph)PLASPEPTK_
PFKFB3 Phosphorylation S475 -0.038 -0.263 _RNS(ph)VTPLASPEPTK_
PFKFB3 Ubiquitylation K306 1.089 -1.079 _FVEEQNLK(gl)DLR_
PFKFB3 Ubiquitylation K125 1.079 _DVK(gl)SYLAK_

Background Information for PFKFB3:


Pubmed-PFKFB3 »
Uniprot-PFKFB3 »
Biogrid-PFKFB3 »
ProteomicsDB-PFKFB3 »

Tumorportal-PFKFB3 »
COSMIC-PFKFB3 »
GenomeRNAi-PFKFB3 »
Genecards-PFKFB3


Protein-protein Interactions for PFKFB3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PES1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PFKFB3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Chromatin_KTI12 IPR013641 0.09
Category members 6Pfruct_kin IPR003094 0.06
Category members Bifunct_6PFK/fruc_bisP_Ptase IPR016260 0.06
Category members His_Pase_superF_clade-1 IPR013078 0
Category members 6Phosfructo_kin IPR013079 0
Category members His_PPase_superfam IPR029033 0


Protein complexes (CORUM database) featuring PFKFB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PFKFB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0006000 fructose metabolic process Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0006003 fructose 2,6-bisphosphate metabolic process Database 0.04
Category members GO Category GO:0003873 6-phosphofructo-2-kinase activity Database 0
Category members GO Category GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity Database 0


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