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Query: PFDN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFDN2 1 1.848 -0.200 0.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFDN2 Ubiquitylation K113 0.306 1.532 _GK(gl)ELNEFR_
PFDN2 Ubiquitylation K18 0.016 0.973 _SSGSGAGK(gl)GAVSAEQVIAGFNR_
PFDN2 Ubiquitylation K94 -0.069 -0.169 _EVLPALENNK(gl)EQIQK_
PFDN2 Ubiquitylation K99 -0.146 _EVLPALENNKEQIQK(gl)_
PFDN2 Ubiquitylation K132 -0.620 _LMGEDEK(gl)PAAK_
PFDN2 Ubiquitylation K136 -0.799 _LMGEDEKPAAK(gl)ENSEGAGAK_

Background Information for PFDN2:


Pubmed-PFDN2 »
Uniprot-PFDN2 »
Biogrid-PFDN2 »
ProteomicsDB-PFDN2 »

Tumorportal-PFDN2 »
COSMIC-PFDN2 »
GenomeRNAi-PFDN2 »
Genecards-PFDN2


Protein-protein Interactions for PFDN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait ECT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21A Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait NSMAF Cat. description Hein, Mann, Cell 2015
Category members IP bait PFDN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR3E Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFDN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PFDN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PFD_beta-like IPR002777 0.31
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring PFDN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 781 URI complex (Unconventional prefoldin RPB5 Interactor) Database 0.77
Category members Corum 112 Prefoldin complex Database 0.27
Category members Corum 33 Prefoldin Database 0.27


Categories featuring PFDN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0051084 'de novo' posttranslational protein folding Database 0.63
Category members Pathway Pathway_1288 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC 0 0.4
Category members GO Category GO:0016272 prefoldin complex Database 0.15


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