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Query: PDE8A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDE8A 0 -0.535 -1.470 2.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDE8A Ubiquitylation K268 -0.004 _ELGEVPINEK(gl)K_
PDE8A Ubiquitylation K269 -0.295 _ELGEVPINEKK(gl)_
PDE8A Phosphorylation S457 -3.296 _RLS(ph)GNEYVLSTK_
PDE8A Ubiquitylation K820 0.571 _GLDEMK(gl)LR_

Background Information for PDE8A:


Pubmed-PDE8A »
Uniprot-PDE8A »
Biogrid-PDE8A »
ProteomicsDB-PDE8A »

Tumorportal-PDE8A »
COSMIC-PDE8A »
GenomeRNAi-PDE8A »
Genecards-PDE8A


Protein-protein Interactions for PDE8A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NR1H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC119 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDE8A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAS_fold IPR013767 0.27
Category members PAS IPR000014 0.23
Category members HD/PDEase_dom IPR003607 0.07
Category members Sig_transdc_resp-reg_receiver IPR001789 0.04
Category members PDEase_catalytic_dom IPR002073 0
Category members CheY-like_superfamily IPR011006 0
Category members PAS_4 IPR013656 0
Category members PDEase IPR023088 0


Protein complexes (CORUM database) featuring PDE8A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDE8A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_253 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 0 0.26
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0000160 phosphorelay signal transduction system Database 0.19
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0000156 phosphorelay response regulator activity Database 0.04
Category members GO Category GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005575 cellular_component Database 0
Category members GO Category GO:0006198 cAMP catabolic process Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009187 cyclic nucleotide metabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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