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Query: PCM1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PCM1 1 1.815 0.060 -0.460
PCM1 1 1.815 0.060 -0.460 -1.645 -0.454

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PCM1 Ubiquitylation K1701 0.384 0.473 _LMQDLDNNSITVK(gl)QR_
PCM1 Phosphorylation S93 1.302 0.355 _YM(ox)SQM(ox)S(ph)VPEQAELEK_
PCM1 Phosphorylation S65 0.290 0.331 _VTNDIS(ph)PESSPGVGR_
PCM1 Phosphorylation S537 0.302 _KDEETEESEYDS(ph)EHENSEPVTNIR_
PCM1 Ubiquitylation K399 0.113 0.218 _VELFSK(gl)MR_
PCM1 Ubiquitylation K738 0.325 0.216 _FYEAK(gl)LQQQQR_
PCM1 Phosphorylation S159 0.298 0.182 _DASTS(ph)PPNRETIGSAQCK_
PCM1 Phosphorylation S1722 -0.145 0.151 _ILEDHGS(ph)PAGEIDDEDKDKDETETVK_
PCM1 Ubiquitylation K218 1.469 0.127 _DYITK(gl)ASSMR_
PCM1 Ubiquitylation K58 -0.013 0.115 _FGVESDK(gl)R_
PCM1 Phosphorylation S861 -0.147 0.081 _RQGLAETAS(ph)PVAVSLR_
PCM1 Phosphorylation S1497 -0.609 0.060 _ISEQNDADNASVLS(ph)VSSNFEPFATDDLGNTVIHLDQALAR_
PCM1 Ubiquitylation K1329 1.103 0.032 _YESASMSSTCEPCK(gl)SR_
PCM1 Phosphorylation T158 -0.294 0.004 _DAST(ph)SPPNRETIGSAQCK_
PCM1 Phosphorylation S1768 -0.066 _SDISDQEEDEES(ph)EGCPVSINLSK_
PCM1 Phosphorylation T3 -0.352 -0.206 _AT(ph)GGGPFEDGMNDQDLPNWSNENVDDR_
PCM1 Ubiquitylation K104 -0.277 _YMSQMSVPEQAELEKLK(gl)_
PCM1 Phosphorylation S960 -0.065 -0.297 _NNCPFS(ph)ADENYRPLAK_
PCM1 Ubiquitylation K1850 -0.282 -0.298 _TAESK(gl)NVPLER_
PCM1 Phosphorylation T1557 0.324 -0.426 _IIEDGDGAGAET(ph)PVIENR_
PCM1 Phosphorylation S1335 -0.465 _NRHS(ph)AQTEEPVQAK_
PCM1 Ubiquitylation K229 0.255 -0.483 _ASSMREDLVEK(gl)NER_
PCM1 Phosphorylation S69 -0.726 -0.667 _VTNDIS(ph)PESS(ph)PGVGR_
PCM1 Phosphorylation S110 -0.658 -0.669 _INFS(ph)DLDQR_
PCM1 Phosphorylation S1494 -0.679 _ISEQNDADNAS(ph)VLSVSSNFEPFATDDLGNTVIHLDQALAR_
PCM1 Ubiquitylation K786 -0.782 _IQALQTACPDLQLSAASVGNCPTK(gl)K_
PCM1 Phosphorylation S68 0.252 -0.806 _VTNDISPES(ph)S(ph)PGVGR_
PCM1 Ubiquitylation K1345 0.813 -0.841 _HSAQTEEPVQAK(gl)VFSR_
PCM1 Ubiquitylation K1197 1.295 -1.001 _NK(gl)KLPEEEVESSR_
PCM1 Ubiquitylation K970 -0.291 -1.144 _NNCPFSADENYRPLAK(gl)TR_
PCM1 Ubiquitylation K393 -3.123 -1.309 _LPDEK(gl)VELFSK_
PCM1 Ubiquitylation K278 -1.778 _ILARDPQQEPMEEIENLKK(gl)_
PCM1 Ubiquitylation K154 -2.495 _SK(gl)DASTSPPNRETIGSAQCK_
PCM1 Ubiquitylation K40 0.041 _LNNMDWGAQQKK(gl)_
PCM1 Ubiquitylation K102 0.263 _YMSQMSVPEQAELEK(gl)LK_
PCM1 Ubiquitylation K139 -0.207 _K(gl)PFNFLPMQINTNK_
PCM1 Ubiquitylation K277 -1.445 _DPQQEPMEEIENLK(gl)K_
PCM1 Ubiquitylation K492 -0.715 _LQK(gl)LNEVR_
PCM1 Ubiquitylation K733 0.099 _EK(gl)FYEAK_
PCM1 Ubiquitylation K747 0.662 _ELK(gl)QLQEER_
PCM1 Ubiquitylation K787 -0.070 _K(gl)YMPAVTSTPTVNQHETSTSK_
PCM1 Ubiquitylation K841 0.123 _K(gl)QLEALMAEHQR_
PCM1 Ubiquitylation K954 -0.737 _WK(gl)NNCPFSADENYRPLAK_
PCM1 Ubiquitylation K1076 -0.746 _LK(gl)QMLNELMR_
PCM1 Ubiquitylation K1181 -0.487 _TEYMAFPK(gl)PFESSSSIGAEKPR_
PCM1 Ubiquitylation K1198 0.580 _K(gl)LPEEEVESSR_
PCM1 Ubiquitylation K1234 1.784 _TGFSVSVEK(gl)STSSNRK_
PCM1 Ubiquitylation K1291 0.298 _ASAQASLASK(gl)DKTPK_
PCM1 Ubiquitylation K1531 1.088 _MK(gl)TEAESNSNMR_
PCM1 Ubiquitylation K1639 0.659 _MVLTLTQQNDESK(gl)EFVK_

Background Information for PCM1:


Pubmed-PCM1 »
Uniprot-PCM1 »
Biogrid-PCM1 »
ProteomicsDB-PCM1 »

Tumorportal-PCM1 »
COSMIC-PCM1 »
GenomeRNAi-PCM1 »
Genecards-PCM1


Protein-protein Interactions for PCM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANKRD26 Cat. description Hein, Mann, Cell 2015
Category members IP bait AZI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C14ORF10;PPP2R3C Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC14 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC77 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCP110 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK5RAP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPJ;DKFZp667E025 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP104 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP120 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP290 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP55 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait CETN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CIT Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK1E Cat. description Hein, Mann, Cell 2015
Category members IP bait DLG5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait HAUS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HAUS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait IMMT Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRRCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MIB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OFD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNT Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2B Cat. description Hein, Mann, Cell 2015
Category members IP bait SDCCAG8 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLAIN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATG14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf96 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf118 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC65 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM81B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFT81 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ING2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LCA5L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC49 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MIS18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NECAB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPICE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSFA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PCM1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring PCM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PCM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0034453 microtubule anchoring Database 0.97
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Disease phenotype THYROID_CARCINOMA_PAPILLARY THYROID CARCINOMA PAPILLARY Database 0.72
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Disease phenotype Papillary_or_follicular_thyroid_carcinoma Papillary or follicular thyroid carcinoma Database 0.09
Category members GO Category GO:0051297 centrosome organization Database 0.04
Category members GO Category GO:0022027 interkinetic nuclear migration Database 0.01
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0034451 centriolar satellite Database 0
Category members GO Category GO:0034454 microtubule anchoring at centrosome Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0050768 negative regulation of neurogenesis Database 0


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