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Query: OTUB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
OTUB1 0 2.092 0.620 -0.500 0.084

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
OTUB1 Ubiquitylation K110 0.919 1.089 _EYAEDDNIYQQKIK(gl)_
OTUB1 Ubiquitylation K108 0.653 0.261 _EYAEDDNIYQQK(gl)IK_
OTUB1 Ubiquitylation K238 -1.014 _TVK(gl)EFCQQEVEPMCK_
OTUB1 Ubiquitylation K121 0.102 _K(gl)TRPDGNCFYR_

Background Information for OTUB1:


Pubmed-OTUB1 »
Uniprot-OTUB1 »
Biogrid-OTUB1 »
ProteomicsDB-OTUB1 »

Tumorportal-OTUB1 »
COSMIC-OTUB1 »
GenomeRNAi-OTUB1 »
Genecards-OTUB1


Protein-protein Interactions for OTUB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2E3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in OTUB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members OTU IPR003323 0.18
Category members Ubiquitin_thioesterase_Otubain IPR016615 0.11
Category members Peptidase_C65_otubain IPR019400 0


Protein complexes (CORUM database) featuring OTUB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring OTUB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0071108 protein K48-linked deubiquitination Database 0.88
Category members GO Category GO:0008242 omega peptidase activity Database 0.28
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0019538 protein metabolic process Database 0
Category members GO Category GO:0019784 NEDD8-specific protease activity Database 0


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