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bioLOGIC Data

Query: NUF2

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
NUF2	0	2.595	-1.320	2.310	0.090

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
NUF2	Ubiquitylation	K402		0.810	_IK(gl)LGIQQLK_
NUF2	Phosphorylation	S247	0.232	0.131	_IVDS(ph)PEKLK_
NUF2	Ubiquitylation	K383		0.024	_TVIEDCNKVQEK(gl)R_
NUF2	Ubiquitylation	K29		-0.101	_ILTGADGK(gl)NLTK_
NUF2	Ubiquitylation	K241		-0.794	_EIQESLK(gl)TK_
NUF2	Ubiquitylation	K115	-0.978	-0.925	_VNDFETADILCPKAK(gl)_
NUF2	Ubiquitylation	K113		-1.246	_VNDFETADILCPK(gl)AK_

Background Information for NUF2:

Pubmed-NUF2 »

Uniprot-NUF2 »

Biogrid-NUF2 »

ProteomicsDB-NUF2 »

Tumorportal-NUF2 »

COSMIC-NUF2 »

GenomeRNAi-NUF2 »

Genecards-NUF2

Protein-protein Interactions for NUF2

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait C20orf172;DSN1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CASC5	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MAX	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait MIS12	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NDC80	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NUF2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait SMC1A	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait SPC24	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TSNAX	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ZWINT	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait C6orf141	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CENPC1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait DSN1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait EXOC1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait NSL1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PMF1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PPP1CC	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SPC24	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SPC25	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait WDYHV1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait ZWINT	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in NUF2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)

Protein complexes (CORUM database) featuring NUF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	127	NDC80 kinetochore complex	Database	0

Categories featuring NUF2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005829	cytosol	Database	INF
Category members	Pathway	Pathway_320	REACTOME_CELL_CYCLE	0	11.08
Category members	GO Category	GO:0000278	mitotic cell cycle	Database	10.63
Category members	Pathway	Pathway_321	REACTOME_MITOTIC_M_M_G1_PHASES	0	5.47
Category members	Pathway	Pathway_323	REACTOME_DNA_REPLICATION	0	5.24
Category members	Pathway	Pathway_317	REACTOME_CELL_CYCLE_MITOTIC	0	4.82
Category members	Pathway	Pathway_726	REACTOME_MITOTIC_PROMETAPHASE	0	2.41
Category members	GO Category	GO:0007067	mitosis	Database	2.23
Category members	GO Category	GO:0000777	condensed chromosome kinetochore	Database	0.32
Category members	GO Category	GO:0000775	chromosome, centromeric region	Database	0.29
Category members	GO Category	GO:0007059	chromosome segregation	Database	0.13
Category members	GO Category	GO:0003674	molecular_function	Database	0.08
Category members	GO Category	GO:0031262	Ndc80 complex	Database	0