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Query: NFS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NFS1 0 -1.147 0.380 -0.880 -0.271 -1.202 -0.210 0.381 0.155

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for NFS1:





Protein-protein Interactions for NFS1

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCOR Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TACC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACAD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDNF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC1LI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DPB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRRF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait N6AMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFAB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCGF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZWINT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NFS1

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cysteine_dSase_NifS IPR016454 0.08
Category members Aminotrans_V_dom IPR000192 0
Category members DegT/StrS_aminotransferase IPR000653 0
Category members ArAA_b-elim_lyase/Thr_aldolase IPR001597 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring NFS1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NFS1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members GO Category GO:0000096 sulfur amino acid metabolic process Database 0.15
Category members Disease phenotype Severe_neonatal_lactic_acidosis_due_to_NFS1-ISD11_complex_deficiency Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency Database 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0018283 iron incorporation into metallo-sulfur cluster Database 0.08
Category members GO Category GO:0032324 molybdopterin cofactor biosynthetic process Database 0.08
Category members GO Category GO:0006520 cellular amino acid metabolic process Database 0
Category members GO Category GO:0006534 cysteine metabolic process Database 0
Category members GO Category GO:0006777 Mo-molybdopterin cofactor biosynthetic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0016829 lyase activity Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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