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Query: MTHFD2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTHFD2 1 -1.281 2.190 -0.950 0.004 -0.468 -0.052

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MTHFD2 Ubiquitylation K194 -1.229 _TGIPTLGK(gl)NVVVAGR_

Background Information for MTHFD2:


Pubmed-MTHFD2 »
Uniprot-MTHFD2 »
Biogrid-MTHFD2 »
ProteomicsDB-MTHFD2 »

Tumorportal-MTHFD2 »
COSMIC-MTHFD2 »
GenomeRNAi-MTHFD2 »
Genecards-MTHFD2


Protein-protein Interactions for MTHFD2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LMNA Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACAA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTHFD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MTHFD2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members THF_DH/CycHdrlase IPR000672 0
Category members THF_DH/CycHdrlase_cat_dom IPR020630 0
Category members THF_DH/CycHdrlase_NAD-bd_dom IPR020631 0


Protein complexes (CORUM database) featuring MTHFD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MTHFD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0046653 tetrahydrofolate metabolic process Database 0.91
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0009396 folic acid-containing compound biosynthetic process Database 0.09
Category members Pathway Pathway_7 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM 0 0.08
Category members GO Category GO:0042301 phosphate ion binding Database 0.07
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0004477 methenyltetrahydrofolate cyclohydrolase activity Database 0
Category members GO Category GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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