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Query: MSN

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MSN 2 1.892 0.650 -0.510 0.207 0.680
MSN 2 1.892 0.650 -0.510 2.501 -2.209 0.246 0.091

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MSN Ubiquitylation K209 1.166 1.594 _IAQDLEM(ox)YGVNYFSIK(gl)NK_
MSN Ubiquitylation K211 1.166 1.594 _IAQDLEM(ox)YGVNYFSIK(gl)NK_
MSN Ubiquitylation K162 1.580 0.660 _VMDQHK(gl)LTR_
MSN Ubiquitylation K139 1.519 0.361 _FGDYNK(gl)EVHK_
MSN Ubiquitylation K344 0.598 0.235 _EK(gl)EELMLR_
MSN Ubiquitylation K450 0.393 0.174 _AK(gl)EAQDDLVK_
MSN Ubiquitylation K79 0.172 -0.032 _ENPLQFK(gl)FR_
MSN Ubiquitylation K3 -0.313 -0.251 _PK(gl)PINVR_
MSN Ubiquitylation K139 1.469 -0.322 _YGDFNK(gl)EVHK_
MSN Ubiquitylation K79 0.043 -0.365 _ESPLLFK(gl)FR_
MSN Ubiquitylation K352 -0.154 -0.543 _LK(gl)QIEEQTKK_
MSN Ubiquitylation K253 -0.069 _NISFNDK(gl)K_
MSN Ubiquitylation K263 -0.786 _K(gl)APDFVFYAPR_
MSN Ubiquitylation K357 -0.003 _LQDYEEK(gl)TK_
MSN Ubiquitylation K359 0.051 _LQDYEEK(gl)TK_
MSN Ubiquitylation K72 0.197 _K(gl)ESPLLFK_
MSN Ubiquitylation K162 0.727 _VLEQHK(gl)LNK_
MSN Ubiquitylation K165 0.697 _VLEQHK(gl)LNKDQWEER_
MSN Ubiquitylation K328 0.763 _AMLENEKK(gl)_

Background Information for MSN:


Pubmed-MSN »
Uniprot-MSN »
Biogrid-MSN »
ProteomicsDB-MSN »

Tumorportal-MSN »
COSMIC-MSN »
GenomeRNAi-MSN »
Genecards-MSN


Protein-protein Interactions for MSN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC13 Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EZR Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MSN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ez/rad/moesin_like IPR000798 0.38
Category members FERM_N IPR018979 0.36
Category members FERM_PH-like_C IPR018980 0.35
Category members Band_41_fam IPR019750 0.33
Category members FERM_domain IPR000299 0
Category members Moesin_tail IPR008954 0
Category members ERM IPR011174 0
Category members ERM_C_dom IPR011259 0
Category members FERM_central IPR019748 0
Category members Band_41_domain IPR019749 0


Protein complexes (CORUM database) featuring MSN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MSN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0005902 microvillus Database 0.13
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members GO Category GO:0001931 uropod Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0019898 extrinsic to membrane Database 0
Category members GO Category GO:0022614 membrane to membrane docking Database 0
Category members GO Category GO:0031528 microvillus membrane Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0


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