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Query: MKL1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MKL1 1 12.103 -1.300 2.170

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MKL1 Phosphorylation S156 9.908 _VSEPLLSATSAS(ph)PTQVVSQLPMGR_
MKL1 Phosphorylation T447 0.025 -0.220 _FGST(ph)GSTPPVS(ph)PTPSER_
MKL1 Phosphorylation S454 -0.079 -0.336 _FGSTGST(ph)PPVS(ph)PTPSER_
MKL1 Phosphorylation T450 -0.735 -0.359 _FGSTGST(ph)PPVS(ph)PTPSER_

Background Information for MKL1:


Pubmed-MKL1 »
Uniprot-MKL1 »
Biogrid-MKL1 »
ProteomicsDB-MKL1 »

Tumorportal-MKL1 »
COSMIC-MKL1 »
GenomeRNAi-MKL1 »
Genecards-MKL1


Protein-protein Interactions for MKL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MKL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members RPEL_repeat IPR004018 0.09


Protein complexes (CORUM database) featuring MKL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MKL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043522 leucine zipper domain binding Database 0.15
Category members GO Category GO:0000976 transcription regulatory region sequence-specific DNA binding Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members GO Category GO:0003785 actin monomer binding Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0051145 smooth muscle cell differentiation Database 0


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