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Query: MKI67

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MKI67 1 5.388 -1.190 2.200
MKI67 1 5.388 -1.190 2.200 -0.354 0.045 -0.341 -0.412

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MKI67 Phosphorylation S859 1.495 _MTSLETKTS(ph)DTETEPSK_
MKI67 Phosphorylation T861 1.254 _MTSLETKTSDT(ph)ETEPSK_
MKI67 Phosphorylation T1764 -0.467 0.853 _KADT(ph)EEEFLAFRK_
MKI67 Phosphorylation S1864 0.768 _ILCKSPQS(ph)DPADTPTNTK_
MKI67 Phosphorylation S308 -0.253 0.573 _SGGSGHAVAEPAS(ph)PEQELDQNKGK_
MKI67 Phosphorylation S1861 -0.093 0.375 _S(ph)PQSDPADTPTNTK_
MKI67 Phosphorylation S1679 0.307 _AFMES(ph)PKQILDSAASLTGSK_
MKI67 Phosphorylation S2002 -0.459 0.297 _LKIS(ph)LGK_
MKI67 Phosphorylation S66 0.295 _SSFSS(ph)DPDESEGIPLK_
MKI67 Phosphorylation S1636 -0.407 0.255 _LKTS(ph)LGK_
MKI67 Ubiquitylation K145 0.249 _AYSK(gl)ITEGK_
MKI67 Phosphorylation S1546 0.248 _AMHTPKPAVS(ph)GEK_
MKI67 Phosphorylation T1335 -0.784 0.190 _RPQT(ph)PKEEAQALEDLTGFK_
MKI67 Phosphorylation S2223 -0.369 0.186 _IACRS(ph)PQPDPVGTPTIFKPQSK_
MKI67 Phosphorylation S62 0.170 _S(ph)SFSSDPDESEGIPLK_
MKI67 Phosphorylation S63 0.170 _S(ph)SFSSDPDESEGIPLK_
MKI67 Phosphorylation T2089 0.088 _ELFQTPDHT(ph)EESTTDDKTTK_
MKI67 Phosphorylation S2505 -0.920 0.060 _LTRTS(ph)GETTQTHTEPTGDSK_
MKI67 Phosphorylation S2466 0.502 0.056 _ITEVSCKS(ph)PQPESFK_
MKI67 Phosphorylation S2827 -0.334 0.010 _IPCKS(ph)SPELEDTATSSK_
MKI67 Phosphorylation S374 0.125 -0.002 _RES(ph)VNLGK_
MKI67 Phosphorylation S2828 -0.514 -0.022 _IPCKSS(ph)PELEDTATSSK_
MKI67 Phosphorylation S1131 -1.023 -0.110 _IACKS(ph)PPPESVDTPTSTK_
MKI67 Phosphorylation S579 -0.743 -0.139 _AQSLVIS(ph)PPAPS(ph)PR_
MKI67 Phosphorylation T1139 -0.162 _IACKS(ph)PPPESVDT(ph)PTSTK_
MKI67 Phosphorylation S1253 -0.501 -0.162 _IPCDS(ph)PQSDPVDT(ph)PTSTK_
MKI67 Phosphorylation T1503 -0.174 _SQPDPVDT(ph)PTSSKPQSK_
MKI67 Phosphorylation S2105 -0.179 _IACKS(ph)PPPESMDTPTSTR_
MKI67 Phosphorylation S357 -0.594 -0.192 _TPVQYSQQQNS(ph)PQK_
MKI67 Phosphorylation T1261 -0.289 _IPCDS(ph)PQSDPVDT(ph)PTSTK_
MKI67 Phosphorylation T2085 -0.497 -0.289 _ELFQT(ph)PDHTEESTTDDK_
MKI67 Phosphorylation S1376 -1.188 -0.323 _MPCESS(ph)PPESADTPTSTR_
MKI67 Phosphorylation T1091 -0.338 _T(ph)PKEEAQSLEDLAGFK_
MKI67 Phosphorylation T2325 -0.736 -0.401 _ELFQT(ph)PGTDKPTTDEK_
MKI67 Phosphorylation S2344 -0.428 _IACKS(ph)PQPDPVDTPASTK_
MKI67 Phosphorylation T3127 -0.447 _T(ph)SPEM(ox)DIQNPDDGAR_
MKI67 Phosphorylation S3128 -0.447 _T(ph)SPEM(ox)DIQNPDDGAR_
MKI67 Phosphorylation T1355 -1.001 -0.520 _ELFQT(ph)PGHTEEAVAAGK_
MKI67 Phosphorylation T1841 1.558 -0.588 _ELFQT(ph)PCTDNPTTDEK_
MKI67 Phosphorylation T1923 -0.827 -0.682 _DINTFVGT(ph)PVEK_
MKI67 Phosphorylation S2708 -0.885 -0.716 _IPCES(ph)PPLEVVDTTASTK_
MKI67 Phosphorylation S648 -0.490 -0.762 _S(ph)GASEANLIVAK_
MKI67 Phosphorylation T1233 -0.393 -0.784 _ELFQT(ph)PGHTEELVAAGK_
MKI67 Phosphorylation S2588 -1.447 -1.045 _IPCKS(ph)PPPELTDTATSTK_
MKI67 Phosphorylation T2406 -0.865 -1.061 _NINTFVET(ph)PVQK_
MKI67 Phosphorylation S1937 -1.025 -1.075 _LDLLGNLPGS(ph)KR_
MKI67 Phosphorylation T328 -0.907 -1.284 _DVESVQT(ph)PSK_
MKI67 Phosphorylation T1193 -0.793 -1.306 _AFMGT(ph)PVQK_
MKI67 Phosphorylation S1815 -1.043 -1.365 _LDQPGNLPGS(ph)NRR_
MKI67 Phosphorylation S584 -1.951 -1.375 _AQSLVIS(ph)PPAPS(ph)PR_
MKI67 Phosphorylation S1628 -1.391 _SSQPDPDKNPAS(ph)SK_
MKI67 Phosphorylation T1801 -0.637 -1.446 _DINTFLGT(ph)PVQK_
MKI67 Phosphorylation T1111 -1.359 -1.579 _ELFQT(ph)PGPSEESMTDEK_
MKI67 Phosphorylation T1383 -1.586 _M(ox)PCESS(ph)PPESADT(ph)PTSTR_
MKI67 Phosphorylation T1557 -0.639 -1.616 _NIYAFMGT(ph)PVQK_
MKI67 Phosphorylation S2299 -1.891 _LDLPGNLPGS(ph)K_
MKI67 Phosphorylation T1747 -1.287 -1.916 _ASQPDLVDT(ph)PTSSKPQPK_
MKI67 Ubiquitylation K46 -0.119 _IQLPVVSK(gl)QHCK_
MKI67 Ubiquitylation K254 0.949 _SQK(gl)ENVLQYCR_
MKI67 Ubiquitylation K645 0.640 _SQHDILQMICSK(gl)R_
MKI67 Phosphorylation S1329 -0.737 _LDLTENLTGS(ph)KR_
MKI67 Phosphorylation S1375 -0.797 _MPCES(ph)SPPESADTPTSTR_
MKI67 Phosphorylation S1629 -0.543 _SSQPDPDKNPASS(ph)K_
MKI67 Ubiquitylation K1938 -0.189 _LDLLGNLPGSK(gl)R_

Background Information for MKI67:


Pubmed-MKI67 »
Uniprot-MKI67 »
Biogrid-MKI67 »
ProteomicsDB-MKI67 »

Tumorportal-MKI67 »
COSMIC-MKI67 »
GenomeRNAi-MKI67 »
Genecards-MKI67


Protein-protein Interactions for MKI67
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ABI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCP110 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait EZH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20B Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB2L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSK1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MKI67
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FHA_dom IPR000253 2.3
Category members SMAD_FHA_domain IPR008984 0.86


Protein complexes (CORUM database) featuring MKI67
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MKI67
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0034605 cellular response to heat Database 0.18
Category members GO Category GO:0030212 hyaluronan metabolic process Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0007126 meiosis Database 0.01
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0


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