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Query: MFN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MFN1 0 0.576 0.260 -0.710

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MFN1 Ubiquitylation K396 0.001 0.575 _NQMNLLTLDVK(gl)K_
MFN1 Ubiquitylation K395 0.001 0.359 _NQM(ox)NLLTLDVK(gl)KK_
MFN1 Ubiquitylation K447 0.305 _SELNK(gl)HIEDGMGR_
MFN1 Ubiquitylation K336 0.097 _TK(gl)FEQHTIR_
MFN1 Ubiquitylation K653 0.047 _QQFVNYATEK(gl)LR_
MFN1 Ubiquitylation K643 0.028 _AFK(gl)QQFVNYATEK_
MFN1 Ubiquitylation K399 -0.087 _IK(gl)EVTEEVANK_
MFN1 Ubiquitylation K345 -0.106 _AK(gl)QILATVK_
MFN1 Ubiquitylation K442 -0.242 _IYK(gl)SELNK_
MFN1 Ubiquitylation K365 -0.867 _NIMDSVNLAAEDK(gl)R_

Background Information for MFN1:


Pubmed-MFN1 »
Uniprot-MFN1 »
Biogrid-MFN1 »
ProteomicsDB-MFN1 »

Tumorportal-MFN1 »
COSMIC-MFN1 »
GenomeRNAi-MFN1 »
Genecards-MFN1


Protein-protein Interactions for MFN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PLK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MFN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOMM22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MFN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Dynamin_GTPase IPR001401 0.36
Category members Fzo/mitofusin_HR2 IPR006884 0


Protein complexes (CORUM database) featuring MFN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MFN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0008053 mitochondrial fusion Database 0.27
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07


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