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Query: LPP

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LPP 1 1.200 2.280 -1.130

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LPP Ubiquitylation K108 1.200 _VQGNPGGK(gl)TLEER_
LPP Ubiquitylation K461 -0.751 _GQPFYAVEK(gl)K_
LPP Ubiquitylation K462 -0.209 _GQPFYAVEKK(gl)_

Background Information for LPP:


Pubmed-LPP »
Uniprot-LPP »
Biogrid-LPP »
ProteomicsDB-LPP »

Tumorportal-LPP »
COSMIC-LPP »
GenomeRNAi-LPP »
Genecards-LPP


Protein-protein Interactions for LPP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R3A Cat. description Hein, Mann, Cell 2015
Category members IP bait SESTD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBLC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDLIM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WASF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LPP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_LIM IPR001781 0


Protein complexes (CORUM database) featuring LPP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LPP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0008150 biological_process Database 0


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