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Query: LCP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LCP1 0 1.664 1.210 -0.660
LCP1 0 1.664 1.210 -0.660 -0.281 -0.025 -0.001

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LCP1 Ubiquitylation K346 -0.191 0.982 _AESMLQQADK(gl)LGCR_
LCP1 Ubiquitylation K582 0.056 0.862 _SGNLTEDDK(gl)HNNAKYAVSMAR_
LCP1 Ubiquitylation K459 -0.408 0.687 _K(gl)LENCNYAVELGK_
LCP1 Ubiquitylation K547 0.444 _STSIQSFKDK(gl)_
LCP1 Ubiquitylation K458 0.072 _LGANMK(gl)K_
LCP1 Ubiquitylation K437 -1.076 -0.238 _IK(gl)VPVDWSK_
LCP1 Ubiquitylation K52 -1.104 -0.247 _EANMPLPGYK(gl)VR_
LCP1 Ubiquitylation K542 0.040 -0.542 _SSSISSFK(gl)DPK_
LCP1 Ubiquitylation K611 -0.561 _VYALPEDLVEVK(gl)PK_
LCP1 Ubiquitylation K91 0.989 _SSDIAK(gl)TFR_
LCP1 Ubiquitylation K168 -0.584 _AVGDGIVLCK(gl)MINLSVPDTIDER_
LCP1 Ubiquitylation K335 -0.095 _IDINMSGFNETDDLK(gl)R_
LCP1 Ubiquitylation K545 -0.668 _STSIQSFK(gl)DK_
LCP1 Ubiquitylation K587 0.056 _SGNLTEDDK(gl)HNNAKYAVSMAR_
LCP1 Ubiquitylation K613 -0.356 _VYALPEDLVEVKPK(gl)_
LCP1 Ubiquitylation K456 -0.408 _K(gl)LENCNYAVELGK_

Background Information for LCP1:


Pubmed-LCP1 »
Uniprot-LCP1 »
Biogrid-LCP1 »
ProteomicsDB-LCP1 »

Tumorportal-LCP1 »
COSMIC-LCP1 »
GenomeRNAi-LCP1 »
Genecards-LCP1


Protein-protein Interactions for LCP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DDX19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LCP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LCP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members EF_hand_dom IPR002048 0


Protein complexes (CORUM database) featuring LCP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LCP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0051017 actin filament bundle assembly Database 0.47
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0002286 T cell activation involved in immune response Database 0.04
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0001891 phagocytic cup Database 0
Category members GO Category GO:0030054 cell junction Database 0


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