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Query: LARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LARS 0 2.834 -0.560 -0.030 -0.418 0.208 -0.616 0.807 0.578

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LARS Ubiquitylation K137 1.292 _TEDIIIK(gl)DK_
LARS Ubiquitylation K139 1.292 _TEDIIIK(gl)DK_
LARS Ubiquitylation K39 0.171 0.356 _VFEVNASNLEK(gl)QTSK_
LARS Ubiquitylation K807 0.450 0.328 _VFASELNAGIIK(gl)TDQNYEK_
LARS Ubiquitylation K155 0.128 _AGSSK(gl)YQWGIMK_
LARS Ubiquitylation K278 -0.011 _VLEPYPSK(gl)LSGLK_
LARS Ubiquitylation K23 -0.097 _EIQQK(gl)WDTER_
LARS Ubiquitylation K984 1.013 -0.320 _VIASELGSMPELKK(gl)_
LARS Ubiquitylation K814 -0.558 _TDQNYEK(gl)MMFK_
LARS Ubiquitylation K647 -0.558 -0.632 _EAPFPK(gl)TQIAK_
LARS Ubiquitylation K43 -1.064 _VFEVNASNLEK(gl)QTSK_
LARS Ubiquitylation K1133 -1.418 _RVPVLGK(gl)EYTEK_
LARS Ubiquitylation K103 0.653 _ACADK(gl)LKR_
LARS Ubiquitylation K1088 0.656 _IEIK(gl)QGDNCDSIIR_

Background Information for LARS:


Pubmed-LARS »
Uniprot-LARS »
Biogrid-LARS »
ProteomicsDB-LARS »

Tumorportal-LARS »
COSMIC-LARS »
GenomeRNAi-LARS »
Genecards-LARS


Protein-protein Interactions for LARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDCCAG8 Cat. description Hein, Mann, Cell 2015
Category members IP bait KARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDCBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Val/Leu/Ile-tRNA-synth_edit IPR009008 0.08
Category members V/L/I-tRNA-synth_anticodon-bd IPR013155 0.08
Category members aa-tRNA-synth_Ia IPR002300 0
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0
Category members Cys-tRNA/MSH_ligase IPR024909 0


Protein complexes (CORUM database) featuring LARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3040 Multisynthetase complex Database 1.78


Categories featuring LARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0002161 aminoacyl-tRNA editing activity Database 0.23
Category members Disease phenotype Acute_infantile_liver_failure-multisystemic_involvement_syndrome Acute infantile liver failure-multisystemic involvement syndrome Database 0.22
Category members GO Category GO:0004823 leucine-tRNA ligase activity Database 0.15
Category members GO Category GO:0006429 leucyl-tRNA aminoacylation Database 0.15
Category members Pathway Pathway_47 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0 0.09


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