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Query: KLHL8

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KLHL8 0 0.029 -0.010 0.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KLHL8 Ubiquitylation K533 -0.461 _SNK(gl)WDYVAALTTPR_

Background Information for KLHL8:


Pubmed-KLHL8 »
Uniprot-KLHL8 »
Biogrid-KLHL8 »
ProteomicsDB-KLHL8 »

Tumorportal-KLHL8 »
COSMIC-KLHL8 »
GenomeRNAi-KLHL8 »
Genecards-KLHL8


Protein-protein Interactions for KLHL8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC120 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GEMIN8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RACGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIGLEC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAF15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KLHL8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kelch_1 IPR006652 0.44
Category members BTB/POZ-like IPR000210 0.43
Category members BACK IPR011705 0.43
Category members BTB/POZ_fold IPR011333 0.36
Category members BTB_POZ IPR013069 0.32
Category members Kelch-like_gigaxonin-typ IPR017096 0.23
Category members Kelch_2 IPR011498 0.2


Protein complexes (CORUM database) featuring KLHL8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring KLHL8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031463 Cul3-RING ubiquitin ligase complex Database 0


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