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Query: INTS12

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INTS12 3 6.179 -1.920 3.040 2.265 2.539 -1.057 -1.379

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INTS12 Phosphorylation S127 0.120 0.499 _LEKPETQS(ph)SPITVQSSK_
INTS12 Phosphorylation S128 0.272 -0.011 _LEKPETQSS(ph)PITVQSSK_

Background Information for INTS12:


Pubmed-INTS12 »
Uniprot-INTS12 »
Biogrid-INTS12 »
ProteomicsDB-INTS12 »

Tumorportal-INTS12 »
COSMIC-INTS12 »
GenomeRNAi-INTS12 »
Genecards-INTS12


Protein-protein Interactions for INTS12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait INTS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait WHSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALDH3A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APLNR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARL13A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDNRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F2RL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILVBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTS12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KDELR3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIR2DS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST6GAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INTS12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91


Protein complexes (CORUM database) featuring INTS12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1155 Integrator-RNAPII complex Database 5.97
Category members Corum 1153 Integrator complex Database 4.67


Categories featuring INTS12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0032039 integrator complex Database 4.79
Category members GO Category GO:0016180 snRNA processing Database 4.67
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0008270 zinc ion binding Database 0.29


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