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Query: IARS2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IARS2 0 1.499 0.170 -0.850 1.007 0.730 -1.398 0.742 0.725

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IARS2 Ubiquitylation K957 -0.307 _EMTADVIELK(gl)GK_

Background Information for IARS2:


Pubmed-IARS2 »
Uniprot-IARS2 »
Biogrid-IARS2 »
ProteomicsDB-IARS2 »

Tumorportal-IARS2 »
COSMIC-IARS2 »
GenomeRNAi-IARS2 »
Genecards-IARS2


Protein-protein Interactions for IARS2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CHORDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPSS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2A Cat. description Hein, Mann, Cell 2015
Category members IP bait UGGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR62 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACSM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBNL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YBEY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IARS2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Val/Leu/Ile-tRNA-synth_edit IPR009008 0.08
Category members V/L/I-tRNA-synth_anticodon-bd IPR013155 0.08
Category members aa-tRNA-synth_Ia IPR002300 0
Category members Ile-tRNA-ligase IPR002301 0
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0


Protein complexes (CORUM database) featuring IARS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring IARS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0002161 aminoacyl-tRNA editing activity Database 0.23
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_47 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0 0.09
Category members Pathway Pathway_203 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION 0 0
Category members GO Category GO:0004822 isoleucine-tRNA ligase activity Database 0
Category members GO Category GO:0006428 isoleucyl-tRNA aminoacylation Database 0


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