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Query: IARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IARS 1 4.430 -1.730 2.410 0.184 -0.127 0.599 0.452

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IARS Ubiquitylation K467 0.326 _FGNWLK(gl)DAR_
IARS Ubiquitylation K149 0.285 _YSAEWK(gl)STVSR_
IARS Phosphorylation S1064 -0.710 -0.587 _APLKPYPVS(ph)PSDK_
IARS Ubiquitylation K902 0.347 _KVTLSTDK(gl)NK_
IARS Ubiquitylation K927 1.883 _GAFK(gl)AVMTSIK_
IARS Ubiquitylation K1068 -1.242 _APLKPYPVSPSDK(gl)VLIQEK_

Background Information for IARS:


Pubmed-IARS »
Uniprot-IARS »
Biogrid-IARS »
ProteomicsDB-IARS »

Tumorportal-IARS »
COSMIC-IARS »
GenomeRNAi-IARS »
Genecards-IARS


Protein-protein Interactions for IARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDCCAG8 Cat. description Hein, Mann, Cell 2015
Category members IP bait AIMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDCBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Val/Leu/Ile-tRNA-synth_edit IPR009008 0.08
Category members V/L/I-tRNA-synth_anticodon-bd IPR013155 0.08
Category members aa-tRNA-synth_Ia IPR002300 0
Category members Ile-tRNA-ligase IPR002301 0
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0


Protein complexes (CORUM database) featuring IARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3040 Multisynthetase complex Database 1.78


Categories featuring IARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members GO Category GO:0002161 aminoacyl-tRNA editing activity Database 0.23
Category members Pathway Pathway_47 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0 0.09
Category members Pathway Pathway_410 ST_INTERLEUKIN_4_PATHWAY 0 0
Category members GO Category GO:0004822 isoleucine-tRNA ligase activity Database 0
Category members GO Category GO:0006428 isoleucyl-tRNA aminoacylation Database 0


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