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Query: HSF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSF2 0 -0.623 0.050 -0.140

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSF2 Ubiquitylation K51 -1.376 _EILPK(gl)YFK_
HSF2 Ubiquitylation K139 -0.710 _VQIK(gl)QETIESR_
HSF2 Ubiquitylation K167 -0.623 _AK(gl)HAQQQQVIR_

Background Information for HSF2:


Pubmed-HSF2 »
Uniprot-HSF2 »
Biogrid-HSF2 »
ProteomicsDB-HSF2 »

Tumorportal-HSF2 »
COSMIC-HSF2 »
GenomeRNAi-HSF2 »
Genecards-HSF2


Protein-protein Interactions for HSF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HSF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC53 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HSF_DNA-bd IPR000232 0.23


Protein complexes (CORUM database) featuring HSF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 655 HSF1-HSF2 complex Database 0


Categories featuring HSF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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