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Query: HSD17B8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSD17B8 1 0.866 -1.560 2.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSD17B8 Ubiquitylation K61 -1.754 _LLGGPGSK(gl)EGPPR_

Background Information for HSD17B8:


Pubmed-HSD17B8 »
Uniprot-HSD17B8 »
Biogrid-HSD17B8 »
ProteomicsDB-HSD17B8 »

Tumorportal-HSD17B8 »
COSMIC-HSD17B8 »
GenomeRNAi-HSD17B8 »
Genecards-HSD17B8


Protein-protein Interactions for HSD17B8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait 3-Sep Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANGPTL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf90 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD17B8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF414 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSD17B8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DH_sc/Rdtase_SDR IPR002198 0
Category members Glc/ribitol_DH IPR002347 0
Category members ADH_insect IPR002424 0
Category members DHB_DH IPR003560 0
Category members PKS_KR IPR013968 0
Category members PKS/FAS_KR IPR020842 0


Protein complexes (CORUM database) featuring HSD17B8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HSD17B8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008210 estrogen metabolic process Database 0.07
Category members Pathway Pathway_89 KEGG_STEROID_HORMONE_BIOSYNTHESIS 0 0
Category members GO Category GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Database 0
Category members GO Category GO:0004303 estradiol 17-beta-dehydrogenase activity Database 0
Category members GO Category GO:0005740 mitochondrial envelope Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0006703 estrogen biosynthetic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008209 androgen metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0047035 testosterone dehydrogenase (NAD+) activity Database 0


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