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Query: HARS2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HARS2 1 -0.486 2.450 -1.340
HARS2 1 -0.486 2.450 -1.340 0.063 -0.497 -1.498 0.366 0.480

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HARS2 Phosphorylation S67 0.313 0.383 _DLS(ph)PQHM(ox)VVR_
HARS2 Ubiquitylation K293 -0.096 _LSQNK(gl)QALEGLGDLK_

Background Information for HARS2:


Pubmed-HARS2 »
Uniprot-HARS2 »
Biogrid-HARS2 »
ProteomicsDB-HARS2 »

Tumorportal-HARS2 »
COSMIC-HARS2 »
GenomeRNAi-HARS2 »
Genecards-HARS2


Protein-protein Interactions for HARS2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKA Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD79A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM174A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GORASP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OTC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMEL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUCLA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YBEY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HARS2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members aa-tRNA-synth_II IPR006195 0.24
Category members aa-tRNA-synt_IIb_cons-dom IPR002314 0
Category members Anticodon-bd IPR004154 0
Category members HisRS/HisZ IPR004516 0
Category members His-tRNA-ligase IPR015807 0


Protein complexes (CORUM database) featuring HARS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HARS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members Disease phenotype Perrault_syndrome Perrault syndrome Database 0.11
Category members Pathway Pathway_203 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION 0 0
Category members GO Category GO:0004821 histidine-tRNA ligase activity Database 0
Category members GO Category GO:0006427 histidyl-tRNA aminoacylation Database 0


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