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Query: HARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HARS 0 1.223 0.230 -0.500
HARS 0 1.223 0.230 -0.500 0.063 -0.497 -1.498 0.366 0.480

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HARS Phosphorylation S67 0.313 0.383 _DLS(ph)PQHM(ox)VVR_
HARS Ubiquitylation K403 -0.202 0.300 _LEALEEK(gl)IR_
HARS Ubiquitylation K444 1.313 0.285 _AELLYKK(gl)_
HARS Ubiquitylation K293 -0.096 _LSQNK(gl)QALEGLGDLK_
HARS Ubiquitylation K53 -0.356 -0.828 _AQLGPDESKQK(gl)_
HARS Ubiquitylation K51 -2.501 _LKAQLGPDESK(gl)QK_

Background Information for HARS:


Pubmed-HARS »
Uniprot-HARS »
Biogrid-HARS »
ProteomicsDB-HARS »

Tumorportal-HARS »
COSMIC-HARS »
GenomeRNAi-HARS »
Genecards-HARS


Protein-protein Interactions for HARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGCZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members S15_NS1_RNA-bd IPR009068 0.28
Category members WHEP-TRS IPR000738 0.27
Category members aa-tRNA-synth_II IPR006195 0.24
Category members aa-tRNA-synt_IIb_cons-dom IPR002314 0
Category members Anticodon-bd IPR004154 0
Category members HisRS/HisZ IPR004516 0
Category members His-tRNA-ligase IPR015807 0


Protein complexes (CORUM database) featuring HARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members Disease phenotype Usher_syndrome_type_3 Usher syndrome type 3 Database 0
Category members GO Category GO:0004821 histidine-tRNA ligase activity Database 0
Category members GO Category GO:0006427 histidyl-tRNA aminoacylation Database 0


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