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Query: GSPT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GSPT1 0 2.845 -0.410 0.980 -0.391 0.223
GSPT1 0 2.845 -0.410 0.980 0.185

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GSPT1 Ubiquitylation K448 0.696 1.152 _FVK(gl)QDQVCIAR_
GSPT1 Ubiquitylation K152 0.084 0.651 _AYFETEKK(gl)_
GSPT1 Ubiquitylation K469 -0.357 0.603 _TAGTICLETFK(gl)DFPQMGR_
GSPT1 Ubiquitylation K490 -0.665 -1.058 _TIAIGK(gl)VLK_
GSPT1 Ubiquitylation K493 -0.390 -1.058 _VLK(gl)LVPEKD_
GSPT1 Ubiquitylation K151 0.084 _AYFETEK(gl)K_
GSPT1 Ubiquitylation K196 0.120 _KGEFETGFEK(gl)GGQTR_

Background Information for GSPT1:


Pubmed-GSPT1 »
Uniprot-GSPT1 »
Biogrid-GSPT1 »
ProteomicsDB-GSPT1 »

Tumorportal-GSPT1 »
COSMIC-GSPT1 »
GenomeRNAi-GSPT1 »
Genecards-GSPT1


Protein-protein Interactions for GSPT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHRM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSPT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GSPT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Transl_B-barrel IPR009000 0.24
Category members Ataxin-2_C IPR009818 0.19
Category members Transl_elong_EFTu/EF1A_C IPR004160 0.01
Category members Transl_elong_EFTu/EF1A_2 IPR004161 0
Category members Transl_elong_EF1A/Init_IF2_C IPR009001 0


Protein complexes (CORUM database) featuring GSPT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GSPT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0003747 translation release factor activity Database 0
Category members GO Category GO:0006479 protein methylation Database 0


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