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bioLOGIC Data

Query: GPHN

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
GPHN	0	-2.060	0.260	-0.330

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
GPHN	Phosphorylation	S283	-1.360	-0.700	_DTASLSTTPSES(ph)PR_
GPHN	Phosphorylation	T279		-1.121	_DTASLSTT(ph)PSES(ph)PR_
GPHN	Phosphorylation	S201		-1.147	_VKEVHDELEDLPS(ph)PPPPLS(ph)PPPTTSPHK_
GPHN	Phosphorylation	S207	-1.761	-2.334	_VKEVHDELEDLPSPPPPLS(ph)PPPTTSPHK_

Background Information for GPHN:

Pubmed-GPHN »

Uniprot-GPHN »

Biogrid-GPHN »

ProteomicsDB-GPHN »

Tumorportal-GPHN »

COSMIC-GPHN »

GenomeRNAi-GPHN »

Genecards-GPHN

Protein-protein Interactions for GPHN

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait CDCA5	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait DYNLL1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PRPF4	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait KLKB1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait KMO	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait LGALS3BP	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait ODF3L2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PRPF4	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait STS	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait TSSK1B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in GPHN

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Mopterin-bd_dom	IPR001453	0

Protein complexes (CORUM database) featuring GPHN

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring GPHN

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005737	cytoplasm	Database	12.81
Category members	GO Category	GO:0005524	ATP binding	Database	5.54
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	GO Category	GO:0005886	plasma membrane	Database	1.21
Category members	GO Category	GO:0005856	cytoskeleton	Database	0.63
Category members	GO Category	GO:0044281	small molecule metabolic process	Database	0.35
Category members	GO Category	GO:0005622	intracellular	Database	0.32
Category members	GO Category	GO:0006767	water-soluble vitamin metabolic process	Database	0.27
Category members	GO Category	GO:0006766	vitamin metabolic process	Database	0.23
Category members	Pathway	Pathway_279	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	0	0.18
Category members	GO Category	GO:0032324	molybdopterin cofactor biosynthetic process	Database	0.08
Category members	GO Category	GO:0016740	transferase activity	Database	0.07
Category members	GO Category	GO:0045211	postsynaptic membrane	Database	0.06
Category members	Pathway	Pathway_1180	BIOCARTA_GABA_PATHWAY	0	0.01
Category members	Disease phenotype	Hereditary_hyperekplexia	Hereditary hyperekplexia	Database	0
Category members	GO Category	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	Database	0
Category members	GO Category	GO:0007529	establishment of synaptic specificity at neuromuscular junction	Database	0
Category members	GO Category	GO:0030054	cell junction	Database	0
Category members	GO Category	GO:0046872	metal ion binding	Database	0