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Query: GAD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GAD1 0 0.141 0.370 0.410

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GAD1 Ubiquitylation K177 -0.269 _DTLK(gl)YGVR_
GAD1 Ubiquitylation K60 -0.704 _TNSLEEK(gl)SR_

Background Information for GAD1:


Pubmed-GAD1 »
Uniprot-GAD1 »
Biogrid-GAD1 »
ProteomicsDB-GAD1 »

Tumorportal-GAD1 »
COSMIC-GAD1 »
GenomeRNAi-GAD1 »
Genecards-GAD1


Protein-protein Interactions for GAD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GAD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GAD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Aminotrans_V_dom IPR000192 0
Category members ArAA_b-elim_lyase/Thr_aldolase IPR001597 0
Category members PyrdxlP-dep_de-COase IPR002129 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring GAD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GAD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_134 KEGG_BETA_ALANINE_METABOLISM 0 0.49
Category members GO Category GO:0006538 glutamate catabolic process Database 0.36
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0045202 synapse Database 0.06
Category members Pathway Pathway_389 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 0 0.04
Category members Disease phenotype Inherited_congenital_spastic_tetraplegia Inherited congenital spastic tetraplegia Database 0.04
Category members Pathway Pathway_272 KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 0 0.04
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members GO Category GO:0048786 presynaptic active zone Database 0.01
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_173 KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM 0 0
Category members Pathway Pathway_390 REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members Pathway Pathway_395 KEGG_TYPE_I_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_396 BIOCARTA_NEUROTRANSMITTERS_PATHWAY 0 0
Category members Pathway Pathway_46 KEGG_BUTANOATE_METABOLISM 0 0
Category members GO Category GO:0004351 glutamate decarboxylase activity Database 0
Category members GO Category GO:0006520 cellular amino acid metabolic process Database 0
Category members GO Category GO:0007269 neurotransmitter secretion Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009449 gamma-aminobutyric acid biosynthetic process Database 0
Category members GO Category GO:0016595 glutamate binding Database 0
Category members GO Category GO:0016829 lyase activity Database 0
Category members GO Category GO:0016831 carboxy-lyase activity Database 0
Category members GO Category GO:0019752 carboxylic acid metabolic process Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0042136 neurotransmitter biosynthetic process Database 0
Category members GO Category GO:0043679 axon terminus Database 0
Category members GO Category GO:0044306 neuron projection terminus Database 0
Category members GO Category GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Database 0


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