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Query: EWSR1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EWSR1 0 -1.705 0.510 -0.870 -1.138 -0.614 0.233 -0.292 -0.394

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EWSR1 Ubiquitylation K433 0.356 -0.237 _AAVEWFDGK(gl)DFQGSK_

Background Information for EWSR1:


Pubmed-EWSR1 »
Uniprot-EWSR1 »
Biogrid-EWSR1 »
ProteomicsDB-EWSR1 »

Tumorportal-EWSR1 »
COSMIC-EWSR1 »
GenomeRNAi-EWSR1 »
Genecards-EWSR1


Protein-protein Interactions for EWSR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EWSR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPN13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFPQ Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EWSR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members Znf_RanBP2 IPR001876 0.18


Protein complexes (CORUM database) featuring EWSR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1768 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.23
Category members Corum 1332 Large Drosha complex Database 0.08


Categories featuring EWSR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Disease phenotype Ewing_sarcoma Ewing sarcoma Database 0.13
Category members Disease phenotype Melanoma_of_soft_parts Melanoma of soft parts Database 0.11
Category members Disease phenotype HISTIOCYTOMA_ANGIOMATOID_FIBROUS HISTIOCYTOMA ANGIOMATOID FIBROUS Database 0.03
Category members Disease phenotype Desmoplastic_small_round_cell_tumor Desmoplastic small round cell tumor Database 0
Category members Disease phenotype Extraskeletal_Ewing_sarcoma Extraskeletal Ewing sarcoma Database 0
Category members Disease phenotype Extraskeletal_myxoid_chondrosarcoma Extraskeletal myxoid chondrosarcoma Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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