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Query: ERCC6L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC6L 0 1.746 -0.140 0.080 0.517 0.478

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERCC6L Phosphorylation S1028 0.533 0.732 _IVS(ph)DGEDEDDSFKDTSSINPFNTSLFQFSSVK_
ERCC6L Phosphorylation S1098 0.526 _S(ph)LINMVLDHVEDMEER_
ERCC6L Phosphorylation S820 0.718 0.467 _GFGS(ph)VEELCTNSSLGMEK_
ERCC6L Phosphorylation S946 0.066 _LEEEPSASS(ph)PQYACDFNLFLEDSADNR_
ERCC6L Phosphorylation S14 -0.164 0.046 _RFPEAEALS(ph)PEQAAHYLR_
ERCC6L Ubiquitylation K55 -0.779 _DIFPNEK(gl)VLSR_

Background Information for ERCC6L:


Pubmed-ERCC6L »
Uniprot-ERCC6L »
Biogrid-ERCC6L »
ProteomicsDB-ERCC6L »

Tumorportal-ERCC6L »
COSMIC-ERCC6L »
GenomeRNAi-ERCC6L »
Genecards-ERCC6L


Protein-protein Interactions for ERCC6L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ERCC6L Cat. description Hein, Mann, Cell 2015
Category members IP bait AARSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFDP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDFY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC6L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members TPR-contain_dom IPR013026 0.97
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35


Protein complexes (CORUM database) featuring ERCC6L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ERCC6L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16


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