bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: EPRS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPRS 2 4.166 0.040 -0.430 0.508 0.472 0.303 0.066 -0.057

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPRS Ubiquitylation K173 1.299 1.648 _WDVSTTK(gl)AR_
EPRS Ubiquitylation K1375 2.482 1.542 _DM(ox)K(gl)SCQFVAVR_
EPRS Ubiquitylation K513 0.230 0.957 _YVALLKK(gl)_
EPRS Ubiquitylation K435 1.097 0.770 _LNLNNTVLSK(gl)R_
EPRS Phosphorylation S885 -0.761 -0.597 _EYIPGQPPLSQSSDS(ph)SPTR_
EPRS Phosphorylation S886 -0.772 -0.706 _EYIPGQPPLSQSSDSS(ph)PTR_
EPRS Phosphorylation S882 -0.761 _EYIPGQPPLSQS(ph)SDS(ph)SPTR_
EPRS Ubiquitylation K603 0.719 _LNLENKDYKK(gl)_
EPRS Ubiquitylation K720 2.584 _TK(gl)VEATKNETSAPFK_
EPRS Ubiquitylation K725 2.090 _TKVEATK(gl)NETSAPFK_
EPRS Ubiquitylation K902 2.407 _NSEPAGLETPEAK(gl)VLFDK_
EPRS Ubiquitylation K907 2.583 _VLFDK(gl)VASQGEVVR_
EPRS Ubiquitylation K1009 2.337 _NQGGGLSSSGAGEGQGPK(gl)K_
EPRS Ubiquitylation K1109 1.853 _SGK(gl)TELAEPIAIRPTSETVMYPAYAK_
EPRS Ubiquitylation K1143 -0.060 _DLPIK(gl)LNQWCNVVR_

Background Information for EPRS:


Pubmed-EPRS »
Uniprot-EPRS »
Biogrid-EPRS »
ProteomicsDB-EPRS »

Tumorportal-EPRS »
COSMIC-EPRS »
GenomeRNAi-EPRS »
Genecards-EPRS


Protein-protein Interactions for EPRS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDCCAG8 Cat. description Hein, Mann, Cell 2015
Category members IP bait AIMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RARS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDCBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPRS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ribosomal_L25/Gln-tRNA_synth IPR011035 0.31
Category members Glu/Gln-tRNA-synth_Ib_codon-bd IPR020059 0.31
Category members S15_NS1_RNA-bd IPR009068 0.28
Category members WHEP-TRS IPR000738 0.27
Category members aa-tRNA-synth_II IPR006195 0.24
Category members Glutathione-S-Trfase_C-like IPR010987 0.23
Category members Glu/Gln-tRNA-synth IPR000924 0.09
Category members Glu/Gln-tRNA-synth_Ib_cat-dom IPR020058 0.09
Category members aa-tRNA-synt_IIb_cons-dom IPR002314 0
Category members Pro-tRNA-ligase_IIa IPR002316 0
Category members GST_C IPR004046 0
Category members Anticodon-bd IPR004154 0


Protein complexes (CORUM database) featuring EPRS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3040 Multisynthetase complex Database 1.78
Category members Corum 5385 GAIT complex Database 1.27


Categories featuring EPRS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds Database 0.42
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0035613 RNA stem-loop binding Database 0.09
Category members GO Category GO:0071346 cellular response to interferon-gamma Database 0.04
Category members Pathway Pathway_81 KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 0 0.01
Category members GO Category GO:0004818 glutamate-tRNA ligase activity Database 0
Category members GO Category GO:0004827 proline-tRNA ligase activity Database 0
Category members GO Category GO:0006424 glutamyl-tRNA aminoacylation Database 0
Category members GO Category GO:0006433 prolyl-tRNA aminoacylation Database 0
Category members GO Category GO:0043039 tRNA aminoacylation Database 0


.

© Copyright Svejstrup Laboratory 2015