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Query: EIF5B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF5B 0 1.081 -0.680 0.560 -0.549 -0.426

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF5B Phosphorylation S113 0.785 0.711 _KQSFDDNDS(ph)EELEDKDSK_
EIF5B Phosphorylation S164 0.547 0.510 _WDGS(ph)EEDEDNSKK_
EIF5B Phosphorylation S107 0.541 0.357 _KQS(ph)FDDNDSEELEDKDSK_
EIF5B Phosphorylation S214 -0.199 -0.105 _NKPGPNIES(ph)GNEDDDASFK_

Background Information for EIF5B:


Pubmed-EIF5B »
Uniprot-EIF5B »
Biogrid-EIF5B »
ProteomicsDB-EIF5B »

Tumorportal-EIF5B »
COSMIC-EIF5B »
GenomeRNAi-EIF5B »
Genecards-EIF5B


Protein-protein Interactions for EIF5B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC42SE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEGS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC29 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF5B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Small_GTP-bd_dom IPR005225 0.32
Category members Transl_B-barrel IPR009000 0.24
Category members Transl_elong_EFTu/EF1A_2 IPR004161 0
Category members TIF_IF2_dom3 IPR023115 0


Protein complexes (CORUM database) featuring EIF5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04


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