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Query: EIF3G

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF3G 1 -4.155 -1.980 3.090
EIF3G 1 -4.155 -1.980 3.090 0.807 -1.194 -0.822 -0.998 -0.788

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF3G Phosphorylation S42 -2.277 -2.062 _GIPLATGDTS(ph)PEPELLPGAPLPPPK_
EIF3G Phosphorylation T41 -2.178 -2.367 _GIPLATGDT(ph)SPEPELLPGAPLPPPK_
EIF3G Ubiquitylation K71 -0.568 _TVTEYK(gl)IDEDGKK_
EIF3G Ubiquitylation K78 -0.010 _TVTEYKIDEDGKK(gl)_
EIF3G Ubiquitylation K148 -0.666 _EDLNCQEEEDPMNK(gl)LK_

Background Information for EIF3G:


Pubmed-EIF3G »
Uniprot-EIF3G »
Biogrid-EIF3G »
ProteomicsDB-EIF3G »

Tumorportal-EIF3G »
COSMIC-EIF3G »
GenomeRNAi-EIF3G »
Genecards-EIF3G


Protein-protein Interactions for EIF3G
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait CERKL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF3G
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34


Protein complexes (CORUM database) featuring EIF3G
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 742 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) Database 1.74
Category members Corum 1097 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) Database 1.41
Category members Corum 4392 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) Database 0.43
Category members Corum 4389 EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) Database 0.18
Category members Corum 4403 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) Database 0.05
Category members Corum 4395 EIF3 complex (EIF3B, EIF3G, EIF3I) Database 0


Categories featuring EIF3G
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0033290 eukaryotic 48S preinitiation complex Database 1.41
Category members GO Category GO:0001731 formation of translation preinitiation complex Database 1.15
Category members GO Category GO:0016282 eukaryotic 43S preinitiation complex Database 1.15
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04


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