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Query: EIF3C

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF3C 1 3.638
EIF3C 1 3.638 1.429 -0.400 -0.701 -0.411 0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF3C Ubiquitylation K494 1.768 _YLEEK(gl)GTTEEVCR_
EIF3C Ubiquitylation K878 -0.805 1.466 _VFDHK(gl)QGTYGGYFR_
EIF3C Ubiquitylation K644 0.671 1.296 _AK(gl)ELLGQGLLLR_
EIF3C Ubiquitylation K333 0.367 1.050 _K(gl)LNEILQAR_
EIF3C Ubiquitylation K554 1.037 _LCK(gl)YIYAK_
EIF3C Phosphorylation S39 0.350 0.387 _QPLLLS(ph)EDEEDTKR_
EIF3C Ubiquitylation K743 1.106 _EHVVAASK(gl)AM(ox)K_
EIF3C Ubiquitylation K746 1.106 _EHVVAASK(gl)AMK_

Background Information for EIF3C:


Pubmed-EIF3C »
Uniprot-EIF3C »
Biogrid-EIF3C »
ProteomicsDB-EIF3C »

Tumorportal-EIF3C »
COSMIC-EIF3C »
GenomeRNAi-EIF3C »
Genecards-EIF3C


Protein-protein Interactions for EIF3C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3F Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3H Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3I Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSPH9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF3C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members PCI_dom IPR000717 2.22


Protein complexes (CORUM database) featuring EIF3C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 742 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) Database 1.74
Category members Corum 1097 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) Database 1.41
Category members Corum 4392 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) Database 0.43


Categories featuring EIF3C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0033290 eukaryotic 48S preinitiation complex Database 1.41
Category members GO Category GO:0001731 formation of translation preinitiation complex Database 1.15
Category members GO Category GO:0016282 eukaryotic 43S preinitiation complex Database 1.15
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0031369 translation initiation factor binding Database 0.1
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04


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