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Query: DTL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DTL 0 -1.286 -0.270 0.310

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DTL Phosphorylation S334 0.437 _ENS(ph)SPENKNWLLAMAAK_
DTL Phosphorylation S335 0.437 _ENS(ph)SPENKNWLLAMAAK_
DTL Ubiquitylation K564 -1.078 0.385 _RLDSSCLESVK(gl)QK_
DTL Phosphorylation S164 -0.379 _RGS(ph)VSSVSPKPPSSFK_
DTL Phosphorylation S191 -1.393 -0.622 _TPSSS(ph)PPIT(ph)PPASETK_
DTL Phosphorylation S169 -0.627 _RGSVSSVS(ph)PKPPSSFK_
DTL Phosphorylation S190 -0.658 _TPSS(ph)SPPIT(ph)PPASETK_
DTL Phosphorylation T195 -1.340 -0.666 _TPSSS(ph)PPIT(ph)PPASETK_
DTL Ubiquitylation K123 -0.865 _LVTAAGDQTAK(gl)FWDVK_
DTL Ubiquitylation K402 -0.938 _GLEEKPGGDK(gl)LSTVGWASQK_
DTL Ubiquitylation K137 -1.095 _AGELIGTCK(gl)GHQCSLK_
DTL Phosphorylation S189 -1.198 _TPS(ph)SSPPITPPASETK_
DTL Ubiquitylation K150 -1.265 _SVAFSK(gl)FEK_
DTL Ubiquitylation K386 -1.694 _IATCSDDNTLK(gl)IWR_
DTL Ubiquitylation K153 -2.286 _FEK(gl)AVFCTGGR_
DTL Ubiquitylation K260 -2.348 _QEPIASK(gl)SFLYPGSSTR_

Background Information for DTL:


Pubmed-DTL »
Uniprot-DTL »
Biogrid-DTL »
ProteomicsDB-DTL »

Tumorportal-DTL »
COSMIC-DTL »
GenomeRNAi-DTL »
Genecards-DTL


Protein-protein Interactions for DTL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT7 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait C9orf41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMK2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFDN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCEAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DTL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring DTL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DTL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0019985 translesion synthesis Database 0.05
Category members GO Category GO:0031465 Cul4B-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0031464 Cul4A-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0


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