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Query: DOCK6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DOCK6 0 3.493 -0.270 0.680
DOCK6 0 3.493 -0.270 0.680 -1.046 0.305 0.146

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DOCK6 Phosphorylation S452 1.041 1.249 _TTS(ph)GDDACNLTSFR_
DOCK6 Phosphorylation S1383 1.049 1.056 _MNS(ph)LTFK_
DOCK6 Phosphorylation S888 0.502 0.610 _SAVRPAS(ph)LNLNR_
DOCK6 Phosphorylation S2129 0.410 _AVLPVTCHRDS(ph)FSR_
DOCK6 Phosphorylation S180 0.319 0.371 _S(ph)MSIDDTPR_
DOCK6 Phosphorylation S946 0.288 _AAPWGSNPS(ph)PSAESTQAMDR_
DOCK6 Phosphorylation S929 0.481 0.241 _SNS(ph)WVNTGGPK_
DOCK6 Phosphorylation S1432 0.204 0.208 _SPS(ph)GSAFGSQENLR_
DOCK6 Ubiquitylation K381 0.138 _LK(gl)SQADQFCQR_
DOCK6 Phosphorylation S1438 -0.052 -0.235 _SPSGSAFGS(ph)QENLR_
DOCK6 Phosphorylation S898 -2.241 -0.434 _SLS(ph)NSNPDISGTPTSPDDEVR_
DOCK6 Phosphorylation T907 -0.613 -0.434 _SLS(ph)NSNPDISGT(ph)PTSPDDEVR_
DOCK6 Phosphorylation S910 -0.268 -0.548 _SLS(ph)NSNPDISGTPTS(ph)PDDEVR_
DOCK6 Phosphorylation S896 -0.852 _S(ph)LSNSNPDISGTPTSPDDEVR_
DOCK6 Phosphorylation S900 -0.947 -3.303 _SLSNS(ph)NPDISGT(ph)PTSPDDEVR_
DOCK6 Phosphorylation S884 -1.058 _SISSS(ph)NPDLAVAPGSVDDEVSR_
DOCK6 Ubiquitylation K2080 0.971 _NK(gl)SLIGPDQKEYQR_
DOCK6 Ubiquitylation K2088 0.652 _SLIGPDQK(gl)EYQR_

Background Information for DOCK6:


Pubmed-DOCK6 »
Uniprot-DOCK6 »
Biogrid-DOCK6 »
ProteomicsDB-DOCK6 »

Tumorportal-DOCK6 »
COSMIC-DOCK6 »
GenomeRNAi-DOCK6 »
Genecards-DOCK6


Protein-protein Interactions for DOCK6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLU Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRP8 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB2A Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB32 Cat. description Hein, Mann, Cell 2015
Category members IP bait REEP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2A Cat. description Hein, Mann, Cell 2015
Category members IP bait ROCK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DOCK8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRCH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF331 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DOCK6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DOCK_C IPR010703 0
Category members DOCK_C/D_N IPR021816 0


Protein complexes (CORUM database) featuring DOCK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DOCK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Disease phenotype Adams-Oliver_syndrome Adams-Oliver syndrome Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0


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